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KMID : 0616120080390030165
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 3 p.165 ~ p.173
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Screening of Inhibitory Effect on Aldose Reductase of Korean Herbal Medicines and Preventive Effect of Catalpa bignonioides against Xylose-induced Lens Opacity (I)
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Lee Yun-Mi
Kim Nan-Hee
Kim Jong-Min
Kim Young-Sook
Jang Dae-Sik
Kim Joo-Hwan
Bae Ki-Hwan
Kim Jin-Sook
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Abstract
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Aldose reductase (AR), the principal enzyme of the polyol pathway, has been shown to play an important role in the diabetic complications, including diabetic cataract. The inhibitors of AR, therefore, would be potential agents for prevention of diabetic complications. As part of our ongoing project directed toward the discovery of preventive and/or treatment for diabetic complications, 48 Korean herbal medicines have been investigated with an in vitro evaluation system using aldose reductase inhibitory activities. Of these, 12 herbal medicines exhibited a significant inhibitory activity against aldose reductase. Particularly, seven herbal medicines, i.e., Eurya japonica, Chrysanthemum indicum, Akebia quinata, Saururus chinensis, Catalpa bignonioides, Lonicera japonica, Vitex rotundifolia showed two times more potent inhibitory activity than the positive control 3.3-tetramethyleneglutaric acid (TMG). In addition, Catalpa bignonioides showed the retardation of cataract-opacification of the lens of the eye under diabetic condition by xylose. Therefore, this result may provide a potential therapeutic approach for preventing and treating diabetic cataracts.
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KEYWORD
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Diabetic cataract, Aldose reductase, AGEs, Korean herbal medicines
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